Effects of Eight-Week Combined Resistance and Endurance Training on Salivary Interleukin-12, Tumor Necrosis Factor, Cortisol, and Testosterone Levels in Patients with Breast Cancer

Background: In recent years, several studies have shown the association between exercise and decreased risk of mortality in patients with breast cancer. However, effects combined resistance endurance training on salivary Interleukin-12 (IL-12), tumor necrosis factor (TNF-α), Cortisol, Testosterone levels cancer not been investigated. Objectives: This study aimed at determining effect 8 weeks IL-12, TNF-α, women Methods: Forty-two postmenopausal were randomly selected divided into (intervention) control groups. The group performed 2 to 3 sets, 10 18 repetitions, 50 70% 1 repetition maximum (1RM), aerobic heart rate (maxHR) (12-14 degrees borg scale) for 20 40 minutes weeks. cortisol, testosterone measured, using enzyme-linked immunosorbent assay (ELISA) method. Two-way analysis variance repeated measure was also used analyze confidence interval 95%. Results: group, there a significant decrease TNF-α levels, TNF-α/IL-12 ratio, variables weight, fat percentage, body mass index (BMI), waist circumference (P < 0.05). Also, results showed increase testosterone/cortisol ratio intervention no changes observed interaction between-group time IL-12 waist–hip (WHR) values > Conclusions: indicate that could be as useful method improve pro-inflammatory factors hormonal Medical oncologists can underline program under their care.